The discussion will take place Thursday at George Washington University and will be streamed live on YouTube. Bush and Clinton will participate via satellite.
Organizers say they hope to build on progress already made in the fight against the devastating virus. The event is sponsored by two organizations, ONE and (RED), that combat global poverty and AIDS. Among the panelists will be Bono, the lead singer of the band U2 and co-founder of ONE and (RED).
Other participants include Tanzania's President Jakaya Mrisho Kikwete, Republican Sen. Marco Rubio of Florida and Democratic congresswoman Barbara Lee of California.