Fitzpatrick leads Bills to 41-7 romp over Chiefs

By DAVE SKRETTA | September 11, 2011 | 4:10 PM EDT

Buffalo Bills wide receiver David Nelson (86) catches a pass while covered by Kansas City Chiefs defensive back Sabby Piscitelli (42) during the first half of an NFL football game at Arrowhead Stadium, Sunday, Sept. 11, 2011, in Kansas City, Mo. (AP Photo/Shane Keyser)

KANSAS CITY, Mo. (AP) — Ryan Fitzpatrick threw four touchdown passes, two of them to journeyman tight end Scott Chandler, and the Buffalo Bills romped to a season-opening 41-7 victory over the Kansas City Chiefs on Sunday.

Fitzpatrick finished with 208 yards passing for the Bills, who who hadn't score 40 points in an opener since a 40-7 victory over the Los Angeles Rams on Sept. 6, 1992.

Fred Jackson added 112 yards rushing for Buffalo.

Matt Cassel threw for 119 yards with a touchdown and interception for Kansas City.

It was the most lopsided season-opening loss in franchise history, and the worst home loss by the Chiefs since a 45-0 loss to the Pittsburgh Steelers 35 years ago.